AB0642 ANTI-SSA POSITIVITY AND SALIVARY GLAND ULTRASOUND AS SCREENING TOOLS FOR PRIMARY SJÖGREN’S SYNDROME IN PATIENTS WITH SICCA SYMPTOMS

Background Salivary Gland ultrasound is a sensitive point of care investigation for the assessment salivary gland dysfunction. It can be abnormal in patients with primary Sjögren’s syndrome(pSS), Sarcoidosis, IgG4 disease, Systemic sclerosis, Infections and Tumors. Objectives To understand utility Anti-SSA, ANA Anti-SSA/SSB diagnosing Syndrome Sicca symptoms. Methods In current study, referred to department Clinical Immunology Rheumatology, King George’s Medical University, Symptoms, Ultrasound was performed those (Hocevar Score ≥1) serological evaluation were performed. The Sensitivity Specificity Hocevar score ≥17 diagnose assessed, ANA, Anti-SSA Anti-SSB positivity assessed. Results A total 78 sicca symptoms included these, 36 diagnosed syndrome 42 other diseases, including 12 Rheumatoid arthritis, 8 lupus erythematosus, 7 systemic 4 related disease Sarcoidosis. did not have any autoimmune rheumatic after evaluation. mean age pSS 36.42 ±11.68 non-pSS 44.45 ±15.31. has sensitivity specificity 80.56% 78.57%, respectively. Adding screening protocol improved but reduced while adding sensitivity, specificity, positive likelihood ration, accuracy area under curve pSS. Conclusion effective tools diagnosis Syndrome. Table 1. Performance different Screening methods + Anti SSA/ SSB SSA 82.35% 78.57% 60.87% 90.00% Positive Likelihood Ratio 3.7593 2.1046 8.2353 Negative 0.2475 0.2899 0.1961 Accuracy 79.49% 73.68% 84.09% Area Under 0.7956 0.7161 0.8618 REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.